Study of ultrastructural changes of the non-neoplastic epithelial disorders of vulva after focused ultrasound treatment. Xanya Sofra Weiss

Cheng-zhi Li†, Xiaogang Liao, Kejian Wang, Yunbo Tian, Niangang Yin & Zhi-biao Wang

Objective:This study was undertaken to investigate the ultrastructural changes of non-neoplastic epithelial disorders of the vulva (known as vulvar dystrophies) after focused ultrasound treatment and to assess the effectiveness of such treatment. Materials & methods: In total, 60 patients with non-neoplastic epithelial disorders of the vulva were enrolled in this study and treated by focused ultrasound therapy. Before and after treatment, changes to ultrastructures in the treatment region were evaluated using pathological and electron microscopic studies in 30 patients and the short-term treatment effectiveness was assessed.
Results: Symptoms of the patients were greatly reduced or even eliminated. There was no itching or pain during sex. Lesions prior to treatment showed various degrees of hyperplastic atrophy and degenerative changes. At the same time, an increase in epithelial keratosic and decrease in melanotic granules and desmosomes was observed. Mitochondria with swelling and capillary contraction were noted. After the focused ultrasound treatment, the epidermis and dermis showed signs of recovery at various levels. The stratified squamous epithelium of vulva had recovered normal stratification and thickness. The pigmentation cells could be obviously seen in the basal layer. Conclusions: The ultrastructural changes of non-neoplastic epithelial disorders of the vulva indicated the disappearance of symptoms of the disease and recovery of the ultrastructures. These results indicate that patients with vulvar dystrophies can be treated with focused ultrasound effectively.

Xanya Sofra Weiss

Xanya Sofra Weiss

Xanya Sofra Weiss

Free radicals play an important role in a number of biological processes, some of which are necessary for life, such as the intracellular killing of bacteria by neutrophil granulocytes. Free radicals have also been implicated in certain cell signalling processes [5]. This is dubbed redox signaling. The two most important oxygen-centered free radicals aresuperoxide and hydroxyl radical. They are derived from molecular oxygen under reducing conditions. However, because of their reactivity, these same free radicals can participate in unwanted side reactions resulting in cell damage. Many forms of cancer are thought to be the result of reactions between free radicals and DNA, resulting inmutations that can adversely affect the cell cycle and potentially lead to malignancy. Some of the symptoms of agingsuch as atherosclerosis are also attributed to free-radical induced oxidation of many of the chemicals making up the body. In addition free radicals contribute to alcohol-induced liver damage, perhaps more than alcohol itself. Radicals in cigarette smoke have been implicated in inactivation of alpha 1-antitrypsin in the lung. This process promotes the development of emphysema. Free radicals may also be involved in Parkinson's disease, senile and drug-induced deafness, schizophrenia, and Alzheimer's. The classic free-radical syndrome, the iron-storage diseasehemochromatosis, is typically associated with a constellation of free-radical-related symptoms including movement disorder, psychosis, skin pigmentary melanin abnormalities, deafness, arthritis, and diabetes mellitus. The free radical theory of aging proposes that free radicals underlie the aging process itself, whereas the process of mitohormesissuggests that repeated exposure to free radicals may extend life span. Because free radicals are necessary for life, the body has a number of mechanisms to minimize free radical induced damage and to repair damage which does occur, such as the enzymes superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase. In addition,antioxidants play a key role in these defense mechanisms. These are often the three vitamins, vitamin A, vitamin C andvitamin E and polyphenol antioxidants. Further, there is good evidence bilirubin and uric acid can act as antioxidants to help neutralize certain free radicals. Bilirubin comes from the breakdown of red blood cells' contents, while uric acid is a breakdown product of purines. Too much bilirubin, though, can lead to jaundice, which could eventually damage the central nervous system, while too much uric acid causes gout [6].

Xanya Sofra Weiss

Xanya Sofra Weiss

Effect of Microcurrent Stimulation on Delayed-Onset Muscle Soreness: A Double-Blind Comparison. Xanya Sofra Weiss

Jennifer D. Allen, MEd, ATC, Carl G. Mattacola, PhD, ATC, and David H. Perrin, PhD, ATC; 1999

Objective:

To examine the efficacy of microcurrent electrical neuromuscular stimulation (MENS) treatment on pain and loss of range of motion (ROM) associated with delayed-onset muscle soreness (DOMS).

Design and Setting:

We assigned subjects to 1 of 2 groups. Group 1 received treatment with microcurrent stimulation (200 μA, 30 Hz, for 10 minutes, then 100 μA, 0.3 Hz, for 10 minutes) 24, 48, and 72 hours after DOMS induction. Group 2 served as a sham group and was treated using a machine altered by the manufacturer so that no current could flow through the electrodes.

Subjects:

DOMS was induced in the biceps brachii of the nondominant arm of 18 subjects (3 males, 15 females: age = 20.33 ± 2.3 years, ht = 170.81 ± 7.3 cm, wt = 69.61 ± 13.1 kg). Dominance was defined as the arm used by the subject to throw a ball.

Measurements:

Subjective pain and active elbow extension ROM were evaluated before and after treatment each day. Two methods were used to assess pain: constant pressure using a weighted Orthoplast sphere and full elbow extension to the limit of pain tolerance. Subjective pain was measured with a graphic rating scale and active elbow extension ROM using a standard, plastic, double-armed goniometer. Three repeated-measures ANOVAs (between-subjects variable was group, within- subjects variables were day and test) were used to assess ROM and pain scores for the 2 groups.

Results:

We found no significant difference in the measurement of subjective pain scores or elbow extension ROM when the MENS group was compared with the sham group.

Conclusions:

Our results indicate that the MENS treatment, within the parameters used for this experiment, was not effective in reducing the pain or loss of ROM associated with delayed-onset muscle soreness.

Xanya Sofra Weiss

Xanya Sofra Weiss

Spatial-Temporal Structures of Human Alpha Rh ythms: Theory, Microcurrent Sources, Multiscale Measurements, and Global Binding of Local Networks. Xan

Paul L. Nunez, Brett M. Wingeier, and Richard B. Silberstein; 2001

Abstract: A theoretical framework supporting experimental measures of dynamic properties of human
EEG is proposed with emphasis on distinct alpha rhythms. Robust relationships between measured
dynamics and cognitive or behavioral conditions are reviewed, and proposed physiological bases for EEG
at cellular levels are considered. Classical EEG data are interpreted in the context of a conceptual
framework that distinguishes between locally and globally dominated dynamic processes, as estimated
with coherence or other measures of phase synchronization. Macroscopic (scalp) potentials generated by
cortical current sources are described at three spatial scales, taking advantage of the columnar structure
of neocortex. NewEEG data demonstrate that both globally coherent and locally dominated behavior can
occur within the alpha band, depending on narrowband frequency, spatial measurement scale, and brain
state. Quasi-stable alpha phase structures consistent with global standing waves are observed. At the
same time, alpha and theta phase locking between cortical regions during mental calculations is demonstrated,consistent with neural network formation. The brain-binding problemis considered in the contextof EEG dynamic behavior that generally exhibits both of these local and global aspects. But specific
experimental designs and data analysis methods may severely bias physiological interpretations in either
local or global directions. Hum. Brain Mapping .

Xanya Sofra Weiss

Xanya Sofra Weiss

CHANGES OF THE COLLAGEN COMPOSITION IN THE HEART CAUSED BY MICROCURRENT APPLICATION. AN EXPLANATION FOR THE IMPROVEMENT OF CARDIAC FUNCTION BY BI-VENT

Johannes Muller, Barbara Kapeller, Gerd Wallukat, Karin Macfelda; 2005

OBJECTIVE: Improvement of cardiac function by the unloading effect of a cardiac assist device mainly depends on the duration of heart failure (HF). Patients with a short history of HF (<> 5 years) do not show significant cardiac function improvement is that the collagen composition of the extracellular matrix is irreversible. It is successful clinical practice to apply microcurrent in patients with bone fractures and wound healing disturbances in order to improve the healing process by modulation of the collagen synthesis. In order to examine whether microcurrent can also influence the collagen synthesis in the myocardium, the effect of microcurrent application on collagen synthesis of adult cardiomyocytes was investigated.
METHODS: Adult cardiomyocytes were isolated and cultivated in 24 well cell culture plates. Current of different magnitudes (0, 20, 40, 60, 80, 100 :A) was applied via platinum electrodes by a special custom-made device. The whole equipment was incubated under cell culture conditions (+37°C, 5% CO2) over a period of 7 days. Changes of the collagen type I and type III synthesis were analyzed using immunohistochemical staining methods. Collagen type I and type III content was quantified using a special fluorescence confocal laser scanning microscopy system including special analysis software.
RESULTS: Compared to cardiomyocytes exposed to 0 :A (control cells), collagen type I synthesis of cardiomyocytes showed no significant change after exposure to a moderate current magnitude(40, 60 :A) but a highly significant mean decrease (20.6 %) if exposed to high current (80, 100 :A). Collagen type III revealed a mean increase at moderate current of 29.7 % and a decrease of 25.2 % at high current exposure. As a side effect, we detected an increase in the cell proliferation rate at moderate and high current.
CONCLUSION: The results obtained in cell culture suggest that the application of micro-current is able to modulate the synthesis of collagen. In particular, in dependency of the current magnitude collagen type I can be up- or down-regulated. Collagen type I is responsible for the stiffness and the degree of dilatation of the heart. Therefore it can be envisaged that this method -if applied clinically - may help to improve cardiac function, as it helps to heal bone fractures.

Xanya Sofra Weiss

Xanya Sofra Weiss

Effects of the application of Aloe vera (L.) and microcurrent on the healing of wounds surgically induced in Wistar rats. Xanya Sofra Weiss

Fernanda Aparecida Sampaio Mendonça; José Roberto Passarini Junior; Marcelo Augusto Marretto Esquisatto; Josué Sampaio Mendonça; Cristina Cruz Franchini; Glaucia Maria Tech dos Santos; 2009

PURPOSE: To investigate the effects of topical application of an Aloe vera gel combined or not with microcurrent application on the healing of skin wounds surgically induced in Wistar rats.
METHODS: The animals were randomly divided into the following groups: control group, animals topically treated with Aloe vera, animals treated with a microcurrent, and animals receiving topical application of Aloe vera combined with microcurrent application.
RESULTS: The results indicated differences in wound healing between the various treatments when compared to the control group. Tissue hyperplasia was lower in the control group compared to the other treated groups. Accelerated wound healing was observed in the group treated with Aloe vera compared to control. Animals submitted to microcurrent application only and the group treated with microcurrent plus Aloe vera presented an earlier onset of the proliferative phase compared to the control group and animals treated with Aloe vera gel alone. Morphometric data confirmed the structural findings.
CONCLUSION: Simultaneous application of Aloe vera gel and microcurrent is an excellent choice for the treatment of open wounds thus indicating a synergistic action of these two applications.

Xanya Sofra Weiss

Xanya Sofra Weiss

Xanya Sofra Weiss

Arasys Inch Loss Arasys Perfector Xanya Xanya Sofra Weiss Xanya Weiss Xanya Sorfa-Weiss Xanyasofraweiss xanyaweiss perfector arasys perfectorarasys arasysperfector inch loss inch-loss body shaping Ion Magnum Pacemaker Technology pacemaker Statins Heart Disease Heart attack Diabetes obesity cellulite cellulite loss nanotechnology nanocurrent pico amperes picoamperes picocurrent marren micro current microcurrents microcurrent face lift non surgical face lift Bio-identical Hormone Therapy Bio-identical Hormones Growth Hormone Free T3 Thyroid Hormones Muscle Building Acne Reduces acne Melasma Reduces Melasma Pigmentations Reduce Pigmentation Reduce Acne

Xanya Sofra Weiss

Xanya Sofra Weiss

Use of growth hormone to boost athletic performance can lead to diabetes, reports a study published ahead of print in the British Journal of Sports Me

Use of growth hormone to boost athletic performance can lead to diabetes, reports a study published ahead of print in the British Journal of Sports Medicine. The study reports the case of a 36 year old professional body-builder who required emergency care for chest pain. He had lost 40 kg in 12 months, during which he had also experienced excessive urination, thirst, and appetite. He admitted to using anabolic steroids for 15 years and artificial growth hormone for the past three. He had also taken insulin, a year after starting on the growth hormone. This was done to counter the effects of high blood sugar, but he had stopped taking it after a couple of episodes of acute low blood sugar (hypoglycaemia) while at the gym. Tests revealed that his liver was inflamed, his kidneys were enlarged and that he had very high blood sugar. He was also dehydrated, and diagnosed with diabetes. He was given intravenous fluids and gradually increasing amounts of insulin over five days, after which he was discharged. His symptoms completely cleared up, and he was no longer diabetic. The use of growth hormone has steadily risen among amateur athletes and bodybuilders all round the world, say the authors, because it is easy to buy online and difficult to detect in screening tests unlike anabolic steroids. The authors believe that this is the first reported case of diabetes associated with the use of high dose growth hormone, and urge anyone taking high doses to regularly check their blood sugar levels.

Xanya Sofra Weiss

Xanya Sofra Weiss

Microcurrent . Xanya Sofra Weiss

Chronic low back pain associated with myofascial trigger point activity has been historically refractory to conventional treatment (Pain Research and Management 7 (2002) 81). In this case series study, an analysis of 22 patients with chronic low back pain, of 8.8 years average duration, is presented. Following treatment with frequency-specific microcurrent, a statistically significant 3.8-fold reduction in pain intensity was observed using a visual analog scale. This outcome was achieved over an average treatment period of 5.6 weeks and a visit frequency of one treatment per week. When pain chronicity exceeded 5 years, there was a trend toward increasing frequency of treatment required to achieve the same magnitude of pain relief.In 90% of these patients, other treatment modalities including drug therapy, chiropractic manipulation, physical therapy, naturopathic treatment and acupuncture had failed to produce equivalent benefits. The microcurrent treatment was the single factor contributing the most consistent difference in patient-reported pain relief.These results support the observation that rigorously designed clinical investigations are warranted.

Xanya Sofra Weiss

Xanya Sofra Weiss