Ronald M Evans,Grant D Barish & Yong-Xu Wang ; 2004
Obesity and the related disorders of dyslipidemia and diabetes (components of syndrome X) have become lobal health epidemics. Over the past decade, the elucidation of key regulators of energy balance and insulin signaling have revolutionized our understanding of fat and sugar metabolism and their intimate link. The three ‘lipid-sensing’ peroxisome proliferator–activated receptors (PPAR-α, PPAR-γand PPAR-δ) exemplify this connection, regulating diverse aspects of lipid and glucose homeostasis, and serving as bona fide therapeutic targets. With molecular underpinnings now in place, new pharmacologic approaches to metabolic disease and new questions are emerging.
Xanya Sofra Weiss
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