T. A. Yakovleva, V. T. Dolgikh, and L. V. Polu~ktov
It was shown previously that prolonged administration of antibacterial antituberculosis preparations (ABP) to intact animals has a cardiotoxic action, manifested by marked destructive and dystrophic changes in the heart muscle [7]. A comparative study of different combinations of ABP showed that a combination of ABP such as isoniazid, prothionamide, and rifampicin may have a marked toxic action on the cardiovascular system [7]~
The investigation described below had two aims: first, to detect and evaluate quantitatively functional and metabolic disturbances of the myocardium arising during prolonged administration of ABP, and second, to attempt to prevent these disturbances by means of the synthetic antioxidant ionol [i].
Xanya Sofra Weiss
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