Protein synthesis-dependent late phase of LTP (L-LTP) is typically induced by repeated high-frequency stimulation (H and is positively correlated with age-related memory loss.Here we report a novel form of protein synthesis-dependen induced by a brief 1-Hz paired-pulse stimulation (PP-1 Hz, 1 min). In contrast to L-LTP induced by HFS, the late animals. Rather, it emerges and becomes enhanced in an age-related way. Thus, in 1.5- to 2-mo-old mice, a brief decaying to baseline in about 90 min. By contrast, PP-1 Hz stimulation induces an enduring and protein synthesis Hz-induced L-LTP is dependent on NMDA receptor activation, requires voltage-dependent calcium channels, and i memory ability declines with aging, the age-related enhancement of L-LTP induced by PP-1 Hz stimulation indic correlated with memory ability.
Xanya Sofra Weiss
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