G. Lally , R. L. M. Faull , H. J. Waldvogel , S. FerrarP, and P. C. Emson; 1997
Calbindin D28 K is a neuronal calcium binding protein which may
act as a buffer of neuronal calcium. Evidence suggests that disturbance of calcium homeostasis is important in neurodegeneration, possibly via changes in calbindin D28K. Immunoreactivity of calbindin D28 N is compared in Alzheimer's disease and age-matched controls. The size and number of calbindin D28 K positive neurons in Alzheimer's disease tissue is reduced. There is also shrinkage of the dendritic tree. Continuing work examines the function of calbindin D28 K using transgenic mice. (J Neural Transm 104:1107-1112)
Xanya Sofra Weiss
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