Multiple Sclerosis: Low-Frequency Temporal Blood Oxygen Level– Dependent Fluctuations Indicate Reduced Functional Connectivity —Initial Results.

PURPOSE: To study the correlation of low-frequency blood oxygenation level– dependent (BOLD) fluctuations on magnetic resonance (MR) images obtained of the left- and right hemisphere primary motor regions in healthy control subjects and patients with multiple sclerosis (MS). MATERIALS AND METHODS: Sixteen healthy volunteers and 20 patients with MS underwent MR imaging with a 1.5-T imager by using a protocol designed to monitor low-frequency BOLD fluctuations. Data for low-frequency BOLD fluctuations were acquired with subjects at rest and during continuous performance of a bilateral fingertapping task. These data were low-pass filtered

Xanya Sofra Weiss

Xanya Sofra Weiss